Following the death of their beloved brother, four sisters (who couldn't be more different) find a way to mend their own broken relationships by tracing the recipients of his organ donations. Allison - a workaholic obstetrician who barely gets time to see her husband and twin sons. As the eldest, she has always felt the burden of looking after the family - first her parents, then her siblings. But now she's not sure she can carry on being the responsible one. Something's got to give. Bridie - following the cult success of her film, Black Box, ten years ago, Bridie's career has stalled, while her husband's acting career is taking off. Bridie is struggling to find the right project to make her comeback - and suddenly realises she could make a film about meeting the transplant recipients... Clare - a hospital nurse, is devastated when her wife Sophie leaves her. After five rounds of IVF and four miscarriages, Sophie cannot deal any longer with Clare's obsession to be a mother. But Clare still has one more embryo in storage - can she/should she still go ahead? Emma - the baby of the family, Emma had always felt overlooked. It was true then and it's still true now. Bullied at school, and reeling from their parents' deaths when she was a teenager, she sought solace in religion. But unable to find a partner who truly shares her beliefs, her life is becoming lonelier and lonelier.
