After the murder of their mother Marisol, sisters Mel and Maggie Vera discovered they not only had an older half-sister, the brilliant geneticist Macy, but that with the 'Power of Three,' they are among the most formidable witches in the world. Having accepted their new destiny as The Charmed Ones, they joined forces with 'Whitelighter' witch advisor Harry Greenwood to stop the impending apocalypse. But saving the world is a tall order, especially when they're not even sure what their place is in that world.