The series follows four people, Eve Baird (Rebecca Romijn), who is chosen by The Library to be a new Guardian, as well as Ezekiel, Cassandra and Jacob, who were asked to apply to the Library to become The Librarian, but weren't chosen in favour of Flynn Carsen (Noah Wyle). While Flynn is searching for the Library (which is lost in time and space during the pilot), the four become a new team of Librarians in order to solve impossible mysteries, recover powerful artifacts, and fight against supernatural threats, especially the forces of the Serpent Brotherhood, led by the mysterious immortal Dulaque (Matt Frewer).
